| 000 -LEADER |
|---|
| fixed length control field |
02393nam a22002177a 4500 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| ISBN |
9781032009100 |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
610.724 |
| Item number |
HAN- |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Handbook of statistical methods for randomized controlled trials / |
| Statement of responsibility, etc |
edited by KyungMann Kim, Frank Bretz, Ying Kuen Cheung, Lisa Victoria Hampson |
| 250 ## - EDITION STATEMENT |
|---|
| Edition statement |
2nd |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication |
Boca Raton : |
| Name of publisher |
CRC Press, |
| Year of publication |
2021. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Number of Pages |
xxxiii, 620p. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references and index. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials.<br/><br/>Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning, monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing, subgroup analysis, competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials, analysis of safety outcomes, non-inferiority trials, incorporating historical data, and validation of surrogate outcomes. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical Term |
Clinical trials |
| General subdivision |
Statistical methods. |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kim, KyungMann |
| Relator term |
editor. |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Bretz, Frank |
| Relator term |
editor. |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Cheung, Ying Kuen ...[et al.] |
| Relator term |
editor. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Books |
